Lezirovitz, Karina, Gleiciele A Vieira-Silva, Ana C Batissoco, Débora Levy, Joao P Kitajima, Alix Trouillet, Ellen Ouyang, et al. “A Rare Genomic Duplication in 2p14 Underlies Autosomal Dominant Hearing Loss DFNA58.” Human Molecular Genetics, April 27, 2020, ddaa075. https://doi.org/10.1093/hmg/ddaa075.
Senn, Pascal, Amir Mina, Stefan Volkenstein, Veronika Kranebitter, Kazuo Oshima, and Stefan Heller. “Progenitor Cells from the Adult Human Inner Ear.” The Anatomical Record 303, no. 3 (2020): 461–70. https://doi.org/10.1002/ar.24228.
Zhu, Ying, Mirko Scheibinger, Daniel Christian Ellwanger, Jocelyn F Krey, Dongseok Choi, Ryan T Kelly, Stefan Heller, and Peter G Barr-Gillespie. “Single-Cell Proteomics Reveals Changes in Expression during Hair-Cell Development.” ELife 8 (November 4, 2019): e50777. https://doi.org/10.7554/eLife.50777.
Jansson, Lina, Michael Ebeid, Jessica W. Shen, Tara E. Mokhtari, Lee A. Quiruz, David M. Ornitz, Sung-Ho Huh, and Alan G. Cheng. “β-Catenin Is Required for Radial Cell Patterning and Identity in the Developing Mouse Cochlea.” Proceedings of the National Academy of Sciences 116, no. 42 (October 15, 2019): 21054–60. https://doi.org/10.1073/pnas.1910223116.
Wang, Tian, Mamiko Niwa, Zahra N. Sayyid, Davood K. Hosseini, Nicole Pham, Sherri M. Jones, Anthony J. Ricci, and Alan G. Cheng. “Uncoordinated Maturation of Developing and Regenerating Postnatal Mammalian Vestibular Hair Cells.” Edited by Walter Marcotti. PLOS Biology 17, no. 7 (July 1, 2019): e3000326. https://doi.org/10.1371/journal.pbio.3000326.
Roccio, Marta, Pascal Senn, and Stefan Heller. “Novel Insights into Inner Ear Development and Regeneration for Targeted Hearing Loss Therapies.” Hearing Research, 2019, 107859. https://doi.org/10.1016/j.heares.2019.107859.
Sayyid, Zahra N., Tian Wang, Leon Chen, Sherri M. Jones, and Alan G. Cheng. “Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System.” Cell Reports 28, no. 2 (2019): 312-324.e4. https://doi.org/10.1016/j.celrep.2019.06.028.
Janesick, Amanda S., and Stefan Heller. “Stem Cells and the Bird Cochlea—Where Is Everybody?” Cold Spring Harbor Perspectives in Medicine 9, no. 4 (2019): a033183. https://doi.org/10.1101/cshperspect.a033183.
Durruthy-Durruthy, Robert, Ethan D. Sperry, Margot E. Bowen, Laura D. Attardi, Stefan Heller, and Donna M. Martin. “Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear.” Frontiers in Genetics 9 (October 23, 2018): 473. https://doi.org/10.3389/fgene.2018.00473.
Roccio, Marta, Michael Perny, Megan Ealy, Hans Ruedi Widmer, Stefan Heller, and Pascal Senn. “Molecular Characterization and Prospective Isolation of Human Fetal Cochlear Hair Cell Progenitors.” Nature Communications 9, no. 1 (2018): 4027. https://doi.org/10.1038/s41467-018-06334-7.
Hartman, Byron H., Robert Bӧscke, Daniel C. Ellwanger, Sawa Keymeulen, Mirko Scheibinger, and Stefan Heller. “Fbxo2 Mouse and Embryonic Stem Cell Reporter Lines Delineate in Vitro-Generated Inner Ear Sensory Epithelia Cells and Enable Otic Lineage Selection and Cre-Recombination.” Developmental Biology 443, no. 1 (2018): 64–77. https://doi.org/10.1016/j.ydbio.2018.08.013.
Ellwanger, Daniel C., Mirko Scheibinger, Rachel A. Dumont, Peter G. Barr-Gillespie, and Stefan Heller. “Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails.” Cell Reports 23, no. 10 (2018): 2901-2914.e13. https://doi.org/10.1016/j.celrep.2018.05.002.
Scheibinger, Mirko, Daniel C. Ellwanger, C. Eduardo Corrales, Jennifer S. Stone, and Stefan Heller. “Aminoglycoside Damage and Hair Cell Regeneration in the Chicken Utricle.” Journal of the Association for Research in Otolaryngology 19, no. 1 (2018): 17–29. https://doi.org/10.1007/s10162-017-0646-4.
DeJonge, Rachel E., Xiao-Ping Liu, Christopher R. Deig, Stefan Heller, Karl R. Koehler, and Eri Hashino. “Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture.” Edited by Jonathan I. Matsui. PLOS ONE 11, no. 9 (September 8, 2016): e0162508. https://doi.org/10.1371/journal.pone.0162508.
Ealy, Megan, Daniel C. Ellwanger, Nina Kosaric, Andres P. Stapper, and Stefan Heller. “Single-Cell Analysis Delineates a Trajectory toward the Human Early Otic Lineage.” Proceedings of the National Academy of Sciences 113, no. 30 (July 26, 2016): 8508–13. https://doi.org/10.1073/pnas.1605537113.
Hartman, Byron H., Robert Durruthy-Durruthy, Roman D. Laske, Steven Losorelli, and Stefan Heller. “Identification and Characterization of Mouse Otic Sensory Lineage Genes.” Frontiers in Cellular Neuroscience 9 (March 19, 2015). https://doi.org/10.3389/fncel.2015.00079.
Huth, Markus E., Kyu-Hee Han, Kayvon Sotoudeh, Yi-Ju Hsieh, Thomas Effertz, Andrew A. Vu, Sarah Verhoeven, et al. “Designer Aminoglycosides Prevent Cochlear Hair Cell Loss and Hearing Loss.” Journal of Clinical Investigation 125, no. 2 (February 2, 2015): 583–92. https://doi.org/10.1172/JCI77424.
Durruthy-Durruthy, Robert, and Stefan Heller. “Applications for Single Cell Trajectory Analysis in Inner Ear Development and Regeneration.” Cell and Tissue Research 361, no. 1 (2015): 49–57. https://doi.org/10.1007/s00441-014-2079-2.
Waldhaus, Jörg, Robert Durruthy-Durruthy, and Stefan Heller. “Quantitative High-Resolution Cellular Map of the Organ of Corti.” Cell Reports 11, no. 9 (2015): 1385–99. https://doi.org/10.1016/j.celrep.2015.04.062.
Wang, Tian, Renjie Chai, Grace S. Kim, Nicole Pham, Lina Jansson, Duc-Huy Nguyen, Bryan Kuo, et al. “Lgr5+ Cells Regenerate Hair Cells via Proliferation and Direct Transdifferentiation in Damaged Neonatal Mouse Utricle.” Nature Communications 6, no. 1 (2015): 6613. https://doi.org/10.1038/ncomms7613.
Durruthy-Durruthy, Robert, Assaf Gottlieb, and Stefan Heller. “3D Computational Reconstruction of Tissues with Hollow Spherical Morphologies Using Single-Cell Gene Expression Data.” Nature Protocols 10, no. 3 (2015): 459–74. https://doi.org/10.1038/nprot.2015.022.
Slattery, Eric L., Kazuo Oshima, Stefan Heller, and Mark E. Warchol. “Cisplatin Exposure Damages Resident Stem Cells of the Mammalian Inner Ear: CISPLATIN EXPOSURE AND STEM CELLS OF THE EAR.” Developmental Dynamics 243, no. 10 (2014): 1328–37. https://doi.org/10.1002/dvdy.24150.
Ronaghi, Mohammad, Marjan Nasr, Megan Ealy, Robert Durruthy-Durruthy, Joerg Waldhaus, Giovanni H. Diaz, Lydia-Marie Joubert, Kazuo Oshima, and Stefan Heller. “Inner Ear Hair Cell-Like Cells from Human Embryonic Stem Cells.” Stem Cells and Development 23, no. 11 (2014): 1275–84. https://doi.org/10.1089/scd.2014.0033.
Durruthy-Durruthy, Robert, Assaf Gottlieb, Byron H. Hartman, Jörg Waldhaus, Roman D. Laske, Russ Altman, and Stefan Heller. “Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution.” Cell 157, no. 4 (2014): 964–78. https://doi.org/10.1016/j.cell.2014.03.036.
Volkenstein, S., K. Oshima, S. T. Sinkkonen, C. E. Corrales, S. P. Most, R. Chai, T. A. Jan, R. van Amerongen, A. G. Cheng, and S. Heller. “Transient, Afferent Input-Dependent, Postnatal Niche for Neural Progenitor Cells in the Cochlear Nucleus.” Proceedings of the National Academy of Sciences 110, no. 35 (August 27, 2013): 14456–61. https://doi.org/10.1073/pnas.1307376110.
Herget, Meike, Mirko Scheibinger, Zhaohua Guo, Taha A. Jan, Christopher M. Adams, Alan G. Cheng, and Stefan Heller. “A Simple Method for Purification of Vestibular Hair Cells and Non-Sensory Cells, and Application for Proteomic Analysis.” Edited by Berta Alsina. PLoS ONE 8, no. 6 (June 4, 2013): e66026. https://doi.org/10.1371/journal.pone.0066026.
Jan, T. A., R. Chai, Z. N. Sayyid, R. van Amerongen, A. Xia, T. Wang, S. T. Sinkkonen, et al. “Tympanic Border Cells Are Wnt-Responsive and Can Act as Progenitors for Postnatal Mouse Cochlear Cells.” Development 140, no. 6 (March 15, 2013): 1196–1206. https://doi.org/10.1242/dev.087528.
Heller, Stefan. “Special Issue on Inner Ear Development and Regeneration.” Hearing Research 297 (2013): 1–2. https://doi.org/10.1016/j.heares.2012.12.009.
Bermingham-McDonogh, O., J. T. Corwin, W. W. Hauswirth, S. Heller, R. Reed, and T. A. Reh. “Regenerative Medicine for the Special Senses: Restoring the Inputs.” Journal of Neuroscience 32, no. 41 (October 10, 2012): 14053–57. https://doi.org/10.1523/JNEUROSCI.3336-12.2012.
Volkenstein, Stefan, John E. Kirkwood, Edwina Lai, Stefan Dazert, Gerald G. Fuller, and Stefan Heller. “Oriented Collagen as a Potential Cochlear Implant Electrode Surface Coating to Achieve Directed Neurite Outgrowth.” European Archives of Oto-Rhino-Laryngology 269, no. 4 (2012): 1111–16. https://doi.org/10.1007/s00405-011-1775-8.
Ronaghi, Mohammad, Marjan Nasr, and Stefan Heller. “Concise Review: Inner Ear Stem Cells-An Oxymoron, but Why?” STEM CELLS 30, no. 1 (2012): 69–74. https://doi.org/10.1002/stem.785.
Sinkkonen, Saku T., Renjie Chai, Taha A. Jan, Byron H. Hartman, Roman D. Laske, Felix Gahlen, Wera Sinkkonen, Alan G. Cheng, Kazuo Oshima, and Stefan Heller. “Intrinsic Regenerative Potential of Murine Cochlear Supporting Cells.” Scientific Reports 1, no. 1 (2011): 26. https://doi.org/10.1038/srep00026.
Sinkkonen, Saku T., Veronika Starlinger, Deepa J. Galaiya, Roman D. Laske, Samuel Myllykangas, Kazuo Oshima, and Stefan Heller. “Serial Analysis of Gene Expression in the Chicken Otocyst.” Journal of the Association for Research in Otolaryngology 12, no. 6 (2011): 697–710. https://doi.org/10.1007/s10162-011-0286-z.
Jörs, Simone, Christian Grimm, Lars Becker, and Stefan Heller. “Genetic Inactivation of Trpml3 Does Not Lead to Hearing and Vestibular Impairment in Mice.” Edited by Hiroaki Matsunami. PLoS ONE 5, no. 12 (December 13, 2010): e14317. https://doi.org/10.1371/journal.pone.0014317.
Diensthuber, M., and S. Heller. “Charakterisierung von Stammzellen des neonatalen auditorischen Sinnesepithels.” HNO 58, no. 11 (2010): 1056–66. https://doi.org/10.1007/s00106-010-2155-1.
Oshima, Kazuo, Steffen Suchert, Nikolas H. Blevins, and Stefan Heller. “Curing Hearing Loss: Patient Expectations, Health Care Practitioners, and Basic Science.” Journal of Communication Disorders 43, no. 4 (2010): 311–18. https://doi.org/10.1016/j.jcomdis.2010.04.002.
Oshima, Kazuo, Kunyoo Shin, Marc Diensthuber, Anthony W. Peng, Anthony J. Ricci, and Stefan Heller. “Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem Cells.” Cell 141, no. 4 (2010): 704–16. https://doi.org/10.1016/j.cell.2010.03.035.
Grimm, Christian, Simone Jörs, S. Adrian Saldanha, Alexander G. Obukhov, Bifeng Pan, Kazuo Oshima, Math P. Cuajungco, Peter Chase, Peter Hodder, and Stefan Heller. “Small Molecule Activators of TRPML3.” Chemistry & Biology 17, no. 2 (2010): 135–48. https://doi.org/10.1016/j.chembiol.2009.12.016.
Peng, A. W., I. A. Belyantseva, P. D. Hsu, T. B. Friedman, and S. Heller. “Twinfilin 2 Regulates Actin Filament Lengths in Cochlear Stereocilia.” Journal of Neuroscience 29, no. 48 (December 2, 2009): 15083–88. https://doi.org/10.1523/JNEUROSCI.2782-09.2009.
Grimm, Christian, Simone Jörs, and Stefan Heller. “Life and Death of Sensory Hair Cells Expressing Constitutively Active TRPML3.” Journal of Biological Chemistry 284, no. 20 (May 15, 2009): 13823–31. https://doi.org/10.1074/jbc.M809045200.
Li, Huawei, Hong Liu, C Eduardo Corrales, Jessica R Risner, Jeff Forrester, Jeffrey R Holt, Stefan Heller, and Albert SB Edge. “Differentiation of Neurons from Neural Precursors Generated in Floating Spheres from Embryonic Stem Cells.” BMC Neuroscience 10, no. 1 (2009): 122. https://doi.org/10.1186/1471-2202-10-122.
Brigande, John V, and Stefan Heller. “Quo Vadis, Hair Cell Regeneration?” Nature Neuroscience 12, no. 6 (2009): 679–85. https://doi.org/10.1038/nn.2311.
Diensthuber, Marc, Kazuo Oshima, and Stefan Heller. “Stem/Progenitor Cells Derived from the Cochlear Sensory Epithelium Give Rise to Spheres with Distinct Morphologies and Features.” Journal of the Association for Research in Otolaryngology 10, no. 2 (2009): 173–90. https://doi.org/10.1007/s10162-009-0161-3.
Oshima, Kazuo, Pascal Senn, and Stefan Heller. “Isolation of Sphere-Forming Stem Cells from the Mouse Inner Ear.” In Auditory and Vestibular Research, edited by Bernd Sokolowski, 493:141–62. Totowa, NJ: Humana Press, 2009. https://doi.org/10.1007/978-1-59745-523-7_9.
Senn, P., and S. Heller. “Stammzellbasierte Ansätze zur Therapie von Innenohrerkrankungen.” HNO 56, no. 1 (2008): 21–26. https://doi.org/10.1007/s00106-007-1652-3.
Grimm, C., M. P. Cuajungco, A. F. J. van Aken, M. Schnee, S. Jors, C. J. Kros, A. J. Ricci, and S. Heller. “A Helix-Breaking Mutation in TRPML3 Leads to Constitutive Activity Underlying Deafness in the Varitint-Waddler Mouse.” Proceedings of the National Academy of Sciences 104, no. 49 (December 4, 2007): 19583–88. https://doi.org/10.1073/pnas.0709846104.
Senn, Pascal, Kazuo Oshima, Dawn Teo, Christian Grimm, and Stefan Heller. “Robust Postmortem Survival of Murine Vestibular and Cochlear Stem Cells.” Journal of the Association for Research in Otolaryngology 8, no. 2 (April 24, 2007): 194–204. https://doi.org/10.1007/s10162-007-0079-6.
Oshima, Kazuo, Christian M. Grimm, C. Eduardo Corrales, Pascal Senn, Rodrigo Martinez Monedero, Gwenaëlle S. G. Géléoc, Albert Edge, Jeffrey R. Holt, and Stefan Heller. “Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear.” Journal of the Association for Research in Otolaryngology 8, no. 1 (February 2, 2007): 18–31. https://doi.org/10.1007/s10162-006-0058-3.
Cuajungco, Math P., Christian Grimm, and Stefan Heller. “TRP Channels as Candidates for Hearing and Balance Abnormalities in Vertebrates.” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1772, no. 8 (2007): 1022–27. https://doi.org/10.1016/j.bbadis.2007.01.002.
Oshima, Kazuo, Dawn Teo, Pascal Senn, Veronika Starlinger, and Stefan Heller. “LIF Promotes Neurogenesis and Maintains Neural Precursors in Cell Populations Derived from Spiral Ganglion Stem Cells.” BMC Developmental Biology 7, no. 1 (2007): 112. https://doi.org/10.1186/1471-213X-7-112.