PUBLICATIONS

SCIENCE AT SCALE

Lezirovitz, K., Vieira-Silva, G. A., Batissoco, A. C., Levy, D., Kitajima, J. P., Trouillet, A., Ouyang, E., Zebajardi, N., Sampaio-Silva, J., Pedroso-Campos, V., Nascimento, L. R., Sonoda, C. Y., Borges, V. M., Vasconcelos, L. G., Beck, R. M. O., Grasel, S. S., Jagger, D. J., Grillet, N., Bento, R. F., … Oiticica, J. (2020). A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58. Human Molecular Genetics, ddaa075. https://doi.org/10.1093/hmg/ddaa075
Senn, P., Mina, A., Volkenstein, S., Kranebitter, V., Oshima, K., & Heller, S. (2020). Progenitor Cells from the Adult Human Inner Ear. The Anatomical Record, 303(3), 461–470. https://doi.org/10.1002/ar.24228
Zhu, Y., Scheibinger, M., Ellwanger, D. C., Krey, J. F., Choi, D., Kelly, R. T., Heller, S., & Barr-Gillespie, P. G. (2019). Single-cell proteomics reveals changes in expression during hair-cell development. ELife, 8, e50777. https://doi.org/10.7554/eLife.50777
Jansson, L., Ebeid, M., Shen, J. W., Mokhtari, T. E., Quiruz, L. A., Ornitz, D. M., Huh, S.-H., & Cheng, A. G. (2019). β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea. Proceedings of the National Academy of Sciences, 116(42), 21054–21060. https://doi.org/10.1073/pnas.1910223116
Wang, T., Niwa, M., Sayyid, Z. N., Hosseini, D. K., Pham, N., Jones, S. M., Ricci, A. J., & Cheng, A. G. (2019). Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells. PLOS Biology, 17(7), e3000326. https://doi.org/10.1371/journal.pbio.3000326
Roccio, M., Senn, P., & Heller, S. (2019). Novel insights into inner ear development and regeneration for targeted hearing loss therapies. Hearing Research, 107859. https://doi.org/10.1016/j.heares.2019.107859
Sayyid, Z. N., Wang, T., Chen, L., Jones, S. M., & Cheng, A. G. (2019). Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System. Cell Reports, 28(2), 312-324.e4. https://doi.org/10.1016/j.celrep.2019.06.028
Janesick, A. S., & Heller, S. (2019). Stem Cells and the Bird Cochlea—Where Is Everybody? Cold Spring Harbor Perspectives in Medicine, 9(4), a033183. https://doi.org/10.1101/cshperspect.a033183
Durruthy-Durruthy, R., Sperry, E. D., Bowen, M. E., Attardi, L. D., Heller, S., & Martin, D. M. (2018). Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear. Frontiers in Genetics, 9, 473. https://doi.org/10.3389/fgene.2018.00473
Roccio, M., Perny, M., Ealy, M., Widmer, H. R., Heller, S., & Senn, P. (2018). Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors. Nature Communications, 9(1), 4027. https://doi.org/10.1038/s41467-018-06334-7
Hartman, B. H., Bӧscke, R., Ellwanger, D. C., Keymeulen, S., Scheibinger, M., & Heller, S. (2018). Fbxo2 mouse and embryonic stem cell reporter lines delineate in vitro-generated inner ear sensory epithelia cells and enable otic lineage selection and Cre-recombination. Developmental Biology, 443(1), 64–77. https://doi.org/10.1016/j.ydbio.2018.08.013
Ellwanger, D. C., Scheibinger, M., Dumont, R. A., Barr-Gillespie, P. G., & Heller, S. (2018). Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails. Cell Reports, 23(10), 2901-2914.e13. https://doi.org/10.1016/j.celrep.2018.05.002
Scheibinger, M., Ellwanger, D. C., Corrales, C. E., Stone, J. S., & Heller, S. (2018). Aminoglycoside Damage and Hair Cell Regeneration in the Chicken Utricle. Journal of the Association for Research in Otolaryngology, 19(1), 17–29. https://doi.org/10.1007/s10162-017-0646-4
DeJonge, R. E., Liu, X.-P., Deig, C. R., Heller, S., Koehler, K. R., & Hashino, E. (2016). Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture. PLOS ONE, 11(9), e0162508. https://doi.org/10.1371/journal.pone.0162508
Ealy, M., Ellwanger, D. C., Kosaric, N., Stapper, A. P., & Heller, S. (2016). Single-cell analysis delineates a trajectory toward the human early otic lineage. Proceedings of the National Academy of Sciences, 113(30), 8508–8513. https://doi.org/10.1073/pnas.1605537113
Hartman, B. H., Durruthy-Durruthy, R., Laske, R. D., Losorelli, S., & Heller, S. (2015). Identification and characterization of mouse otic sensory lineage genes. Frontiers in Cellular Neuroscience, 9. https://doi.org/10.3389/fncel.2015.00079
Huth, M. E., Han, K.-H., Sotoudeh, K., Hsieh, Y.-J., Effertz, T., Vu, A. A., Verhoeven, S., Hsieh, M. H., Greenhouse, R., Cheng, A. G., & Ricci, A. J. (2015). Designer aminoglycosides prevent cochlear hair cell loss and hearing loss. Journal of Clinical Investigation, 125(2), 583–592. https://doi.org/10.1172/JCI77424
Durruthy-Durruthy, R., & Heller, S. (2015). Applications for single cell trajectory analysis in inner ear development and regeneration. Cell and Tissue Research, 361(1), 49–57. https://doi.org/10.1007/s00441-014-2079-2
Waldhaus, J., Durruthy-Durruthy, R., & Heller, S. (2015). Quantitative High-Resolution Cellular Map of the Organ of Corti. Cell Reports, 11(9), 1385–1399. https://doi.org/10.1016/j.celrep.2015.04.062
Wang, T., Chai, R., Kim, G. S., Pham, N., Jansson, L., Nguyen, D.-H., Kuo, B., May, L. A., Zuo, J., Cunningham, L. L., & Cheng, A. G. (2015). Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle. Nature Communications, 6(1), 6613. https://doi.org/10.1038/ncomms7613
Durruthy-Durruthy, R., Gottlieb, A., & Heller, S. (2015). 3D computational reconstruction of tissues with hollow spherical morphologies using single-cell gene expression data. Nature Protocols, 10(3), 459–474. https://doi.org/10.1038/nprot.2015.022
Slattery, E. L., Oshima, K., Heller, S., & Warchol, M. E. (2014). Cisplatin exposure damages resident stem cells of the mammalian inner Ear: CISPLATIN EXPOSURE AND STEM CELLS OF THE EAR. Developmental Dynamics, 243(10), 1328–1337. https://doi.org/10.1002/dvdy.24150
Ronaghi, M., Nasr, M., Ealy, M., Durruthy-Durruthy, R., Waldhaus, J., Diaz, G. H., Joubert, L.-M., Oshima, K., & Heller, S. (2014). Inner Ear Hair Cell-Like Cells from Human Embryonic Stem Cells. Stem Cells and Development, 23(11), 1275–1284. https://doi.org/10.1089/scd.2014.0033
Durruthy-Durruthy, R., Gottlieb, A., Hartman, B. H., Waldhaus, J., Laske, R. D., Altman, R., & Heller, S. (2014). Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution. Cell, 157(4), 964–978. https://doi.org/10.1016/j.cell.2014.03.036
Volkenstein, S., Oshima, K., Sinkkonen, S. T., Corrales, C. E., Most, S. P., Chai, R., Jan, T. A., van Amerongen, R., Cheng, A. G., & Heller, S. (2013). Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus. Proceedings of the National Academy of Sciences, 110(35), 14456–14461. https://doi.org/10.1073/pnas.1307376110
Herget, M., Scheibinger, M., Guo, Z., Jan, T. A., Adams, C. M., Cheng, A. G., & Heller, S. (2013). A Simple Method for Purification of Vestibular Hair Cells and Non-Sensory Cells, and Application for Proteomic Analysis. PLoS ONE, 8(6), e66026. https://doi.org/10.1371/journal.pone.0066026
Jan, T. A., Chai, R., Sayyid, Z. N., van Amerongen, R., Xia, A., Wang, T., Sinkkonen, S. T., Zeng, Y. A., Levin, J. R., Heller, S., Nusse, R., & Cheng, A. G.-L. (2013). Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development, 140(6), 1196–1206. https://doi.org/10.1242/dev.087528
Heller, S. (2013). Special issue on inner ear development and regeneration. Hearing Research, 297, 1–2. https://doi.org/10.1016/j.heares.2012.12.009
Bermingham-McDonogh, O., Corwin, J. T., Hauswirth, W. W., Heller, S., Reed, R., & Reh, T. A. (2012). Regenerative Medicine for the Special Senses: Restoring the Inputs. Journal of Neuroscience, 32(41), 14053–14057. https://doi.org/10.1523/JNEUROSCI.3336-12.2012
Volkenstein, S., Kirkwood, J. E., Lai, E., Dazert, S., Fuller, G. G., & Heller, S. (2012). Oriented collagen as a potential cochlear implant electrode surface coating to achieve directed neurite outgrowth. European Archives of Oto-Rhino-Laryngology, 269(4), 1111–1116. https://doi.org/10.1007/s00405-011-1775-8
Ronaghi, M., Nasr, M., & Heller, S. (2012). Concise Review: Inner Ear Stem Cells-An Oxymoron, but Why? STEM CELLS, 30(1), 69–74. https://doi.org/10.1002/stem.785
Sinkkonen, S. T., Chai, R., Jan, T. A., Hartman, B. H., Laske, R. D., Gahlen, F., Sinkkonen, W., Cheng, A. G., Oshima, K., & Heller, S. (2011). Intrinsic regenerative potential of murine cochlear supporting cells. Scientific Reports, 1(1), 26. https://doi.org/10.1038/srep00026
Sinkkonen, S. T., Starlinger, V., Galaiya, D. J., Laske, R. D., Myllykangas, S., Oshima, K., & Heller, S. (2011). Serial Analysis of Gene Expression in the Chicken Otocyst. Journal of the Association for Research in Otolaryngology, 12(6), 697–710. https://doi.org/10.1007/s10162-011-0286-z
Jörs, S., Grimm, C., Becker, L., & Heller, S. (2010). Genetic Inactivation of Trpml3 Does Not Lead to Hearing and Vestibular Impairment in Mice. PLoS ONE, 5(12), e14317. https://doi.org/10.1371/journal.pone.0014317
Diensthuber, M., & Heller, S. (2010). Charakterisierung von Stammzellen des neonatalen auditorischen Sinnesepithels. HNO, 58(11), 1056–1066. https://doi.org/10.1007/s00106-010-2155-1
Oshima, K., Suchert, S., Blevins, N. H., & Heller, S. (2010). Curing hearing loss: Patient expectations, health care practitioners, and basic science. Journal of Communication Disorders, 43(4), 311–318. https://doi.org/10.1016/j.jcomdis.2010.04.002
Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J., & Heller, S. (2010). Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem Cells. Cell, 141(4), 704–716. https://doi.org/10.1016/j.cell.2010.03.035
Grimm, C., Jörs, S., Saldanha, S. A., Obukhov, A. G., Pan, B., Oshima, K., Cuajungco, M. P., Chase, P., Hodder, P., & Heller, S. (2010). Small Molecule Activators of TRPML3. Chemistry & Biology, 17(2), 135–148. https://doi.org/10.1016/j.chembiol.2009.12.016
Peng, A. W., Belyantseva, I. A., Hsu, P. D., Friedman, T. B., & Heller, S. (2009). Twinfilin 2 Regulates Actin Filament Lengths in Cochlear Stereocilia. Journal of Neuroscience, 29(48), 15083–15088. https://doi.org/10.1523/JNEUROSCI.2782-09.2009
Grimm, C., Jörs, S., & Heller, S. (2009). Life and Death of Sensory Hair Cells Expressing Constitutively Active TRPML3. Journal of Biological Chemistry, 284(20), 13823–13831. https://doi.org/10.1074/jbc.M809045200
Li, H., Liu, H., Corrales, C. E., Risner, J. R., Forrester, J., Holt, J. R., Heller, S., & Edge, A. S. (2009). Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. BMC Neuroscience, 10(1), 122. https://doi.org/10.1186/1471-2202-10-122
Brigande, J. V., & Heller, S. (2009). Quo vadis, hair cell regeneration? Nature Neuroscience, 12(6), 679–685. https://doi.org/10.1038/nn.2311
Diensthuber, M., Oshima, K., & Heller, S. (2009). Stem/Progenitor Cells Derived from the Cochlear Sensory Epithelium Give Rise to Spheres with Distinct Morphologies and Features. Journal of the Association for Research in Otolaryngology, 10(2), 173–190. https://doi.org/10.1007/s10162-009-0161-3
Oshima, K., Senn, P., & Heller, S. (2009). Isolation of Sphere-Forming Stem Cells from the Mouse Inner Ear. In B. Sokolowski (Ed.), Auditory and Vestibular Research (Vol. 493, pp. 141–162). Humana Press. https://doi.org/10.1007/978-1-59745-523-7_9
Senn, P., & Heller, S. (2008). Stammzellbasierte Ansätze zur Therapie von Innenohrerkrankungen. HNO, 56(1), 21–26. https://doi.org/10.1007/s00106-007-1652-3
Grimm, C., Cuajungco, M. P., van Aken, A. F. J., Schnee, M., Jors, S., Kros, C. J., Ricci, A. J., & Heller, S. (2007). A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Proceedings of the National Academy of Sciences, 104(49), 19583–19588. https://doi.org/10.1073/pnas.0709846104
Senn, P., Oshima, K., Teo, D., Grimm, C., & Heller, S. (2007). Robust Postmortem Survival of Murine Vestibular and Cochlear Stem Cells. Journal of the Association for Research in Otolaryngology, 8(2), 194–204. https://doi.org/10.1007/s10162-007-0079-6
Oshima, K., Grimm, C. M., Corrales, C. E., Senn, P., Martinez Monedero, R., Géléoc, G. S. G., Edge, A., Holt, J. R., & Heller, S. (2007). Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear. Journal of the Association for Research in Otolaryngology, 8(1), 18–31. https://doi.org/10.1007/s10162-006-0058-3
Cuajungco, M. P., Grimm, C., & Heller, S. (2007). TRP channels as candidates for hearing and balance abnormalities in vertebrates. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1772(8), 1022–1027. https://doi.org/10.1016/j.bbadis.2007.01.002
Oshima, K., Teo, D., Senn, P., Starlinger, V., & Heller, S. (2007). LIF promotes neurogenesis and maintains neural precursors in cell populations derived from spiral ganglion stem cells. BMC Developmental Biology, 7(1), 112. https://doi.org/10.1186/1471-213X-7-112